Lycopene MetabolismThe bioavailability of lycopene is affected by the form of molecule, the number of lycopene in food, the matrix content of foodstuff, fat medium or oil, the food fibre effect and the interaction with other carotenoid. Lycopene metabolism happens along with fat metabolism. Lycopene is mostly found in several networks such as in testes, adrenal gland, heart and prostat. Recently it is identified 2 lycopene metabolit in serum and mother's milk which is known as cyclolycopene.
Lycopene level in Serum
The level of lycopene in serum is approximately 50-900 ng/L and lasts in 2-3 days. The rate level is in accordance with consumption of riched-lycopene food. Some human lifestyle and condition can influence lycopene level in blood, i.e., age, menstruation cycle, smoking, and alcohol consumption.
Lycopene as Antioxindant
Lycopene is a potent antioxidant. This compound has the capacity to eliminate free radical. The free radical could tie DNA, protein and fat and will damage their physiological function. In turn it can cause the chronic illness expansion like cancer, heart disease and the aging illness. Dr. Giovannucci stresses that likopen is an effective eliminator of free radicals among other general carotenoids.
The work mechanism of lycopene to reduce cancer risk as prostate cancer has not yet been known clearly at this time. it is probable that it is cause by the capability of lycopene to protect the ageing proccess of prostate epitel cells caused by the species of reactive oxygen.
It is also probably because of lycopene capacity to hinder cell proliferation through the process of fosforilasi of IGF receptor, like happening on breasts cancer cells (Karas, and all 2000).
There are two working mechanisms of lycopene to prevent chronic illness, including cancer and degenerative diseases, that is:
Lycopene level in Serum
The level of lycopene in serum is approximately 50-900 ng/L and lasts in 2-3 days. The rate level is in accordance with consumption of riched-lycopene food. Some human lifestyle and condition can influence lycopene level in blood, i.e., age, menstruation cycle, smoking, and alcohol consumption.
Lycopene as Antioxindant
Lycopene is a potent antioxidant. This compound has the capacity to eliminate free radical. The free radical could tie DNA, protein and fat and will damage their physiological function. In turn it can cause the chronic illness expansion like cancer, heart disease and the aging illness. Dr. Giovannucci stresses that likopen is an effective eliminator of free radicals among other general carotenoids.
The work mechanism of lycopene to reduce cancer risk as prostate cancer has not yet been known clearly at this time. it is probable that it is cause by the capability of lycopene to protect the ageing proccess of prostate epitel cells caused by the species of reactive oxygen.
It is also probably because of lycopene capacity to hinder cell proliferation through the process of fosforilasi of IGF receptor, like happening on breasts cancer cells (Karas, and all 2000).
There are two working mechanisms of lycopene to prevent chronic illness, including cancer and degenerative diseases, that is:
- Through oksidative work, i.e, it functions as antioxidant that will stifle the species of reactive oxygen and increase antioxidant potent so as to reduce oxidative damage to the lipid (including the lipid membrane and lipoprotein), protein and DNA.
- By non-oksidatif mechanism through the regulation of gene function, improving gap-junction communication, hormone modulation and the immune response or metabolism regulation that all of them will cause the decline of the risk of chronic illness.
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